Kisspeptin reading list
A few useful entry points, followed by the individual source records.
Read by subject
For desire, the most direct starting point is the trial in men with hypoactive sexual desire disorder. Beside it, the attraction-cue experiment gives a different approach to brain processing. Those are my opening pair for a closer look at libido.
For hormone timing, read the experiment on resetting the GnRH clock in men alongside the report of a fading LH response during repeated administration in women with hypothalamic amenorrhea. The change in population is essential.
For the broader questions, begin with anxiety, food intake in women with overweight or obesity or bone markers in healthy men. A concrete experiment is my preferred doorway into the subject.
The clinical-status review
The systematic review of current clinical status was published in 2025 and identified 29 interventional trials from databases searched through February 2023. Its account of regulatory status and its search window need to travel together.
The reading list ranges from human trials to the cellular and animal experiments discussed in the essays.
- KiSS-1, a novel human malignant melanoma metastasis-suppressor gene ↗
- The GPR54 gene as a regulator of puberty ↗
- Inactivating KISS1 mutation and hypogonadotropic hypogonadism ↗
- Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males ↗
- Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men ↗
- Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis ↗
- Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of kisspeptin-54 ↗
- Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial ↗
- Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men ↗
- Kisspeptin administration stimulates reproductive hormones but does not affect anxiety in humans ↗
- The effects of kisspeptin on food intake in women with overweight or obesity ↗
- Acute effects of kisspeptin administration on bone metabolism in healthy men ↗
- Kisspeptin and its current clinical status - a systematic review ↗
- Kisspeptin resets the hypothalamic GnRH clock in men ↗
- Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism ↗
- KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis ↗
- Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans ↗
- Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src ↗
- Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels ↗
- Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy ↗